80 Active Trials. 4,000 Essential Documents. Your TMF Is Never Inspection-Ready.

Thousands of TMF documents across multiple sponsors. ICH-GCP compliance tracked in spreadsheets. Regulatory submission packages assembled manually for every country filing. Site monitoring reports taking days to process. DxLogic builds AI workflows that automate the documentation overhead — so your clinical operations teams focus on trial execution, not paperwork.

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$2M+
Annual Documentation Savings
80%
Faster TMF Readiness
60 days
First Workflow Live
01
Document Arrives
02
AI Extracts & Validates
03
Routed & Done

AI Workflows We Build for Enterprise CROs

Purpose-built automation for full-service CROs, functional service providers, and site management organizations.

Trial Master File Management

AI monitors TMF completeness across every study and every sponsor in real-time. Tracks essential documents against ICH-GCP reference models, flags missing artifacts the day they’re due, and maintains audit-ready status continuously — across hundreds of concurrent trials.

100% TMF completeness at inspection
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Site Monitoring & Visit Reports

AI processes monitoring visit reports from every CRA across every site. Extracts findings, flags protocol deviations, tracks action item resolution, and generates trend analysis across your entire site portfolio. Your clinical operations team manages by exception, not by report review.

90% faster report processing
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Regulatory Submissions & Country Filings

AI assembles regulatory submission packages — CTAs, INDs, safety updates, and country-specific filings. Cross-references against FDA, EMA, and ICH requirements per jurisdiction. Your regulatory affairs team reviews complete packages instead of assembling from scratch across multi-country trials.

75% less prep time per submission
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Safety Reporting & Pharmacovigilance

AI monitors adverse event data across trials and sponsors. Detects signals, validates reporting timelines against ICH E2B requirements, and generates safety narratives. Flags potential expedited reporting obligations before deadlines are breached. Your PV team acts on signals, not spreadsheet reviews.

Zero missed reporting deadlines
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Sponsor Reporting & Metrics

AI consolidates data from CTMS, EDC, eTMF, and safety databases into sponsor-ready dashboards and reports. Enrollment status, site performance, protocol deviations, and financial metrics — delivered on schedule without manual compilation. Every sponsor gets their data in their format.

Real-time cross-study visibility
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Study Startup & Essential Documents

AI tracks essential document collection across sites — IRB/IEC approvals, regulatory authority notifications, investigator CVs, lab certifications, insurance certificates. Flags missing documents per site, per country, per sponsor requirement. Your startup team activates sites faster.

40% faster site activation
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Results from CROs Like Yours

How enterprise CROs eliminated documentation bottlenecks and saw measurable ROI.

Case Study
TMF Audit Readiness From 6-Week Remediation to Always-On — $2.4M in Annual Savings
A full-service CRO managing 80+ concurrent studies across 12 sponsors was spending 6 weeks remediating TMF gaps before every sponsor audit and regulatory inspection. Quality teams manually tracked 4,000+ essential documents per study. Missing artifacts were discovered weeks before inspections, triggering emergency remediation that pulled CRAs off active monitoring. DxLogic built a TMF completeness workflow that monitors every essential document in real-time, flags gaps the day they appear, and maintains inspection-ready status continuously. Remediation cycles eliminated. Two FTE equivalents redeployed from TMF tracking to clinical oversight.
$2.4M Annual Savings | 80+ Studies Always Inspection-Ready
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Built for Teams Running These Operations

If any of these describe your organization, we built this for you.

Full-Service CROs

Dozens of sponsors, hundreds of sites, multi-jurisdiction regulatory filings. AI unifies the documentation flowing between clinical operations, regulatory affairs, pharmacovigilance, and quality — giving leadership real-time visibility across the entire trial portfolio.

Functional Service Providers (FSPs)

Embedded in sponsor teams with different CTMS, eTMF, and safety systems. AI normalizes data across sponsor platforms so your teams deliver consistent quality and reporting — regardless of the sponsor’s technology stack or process requirements.

Site Management Organizations (SMOs)

Managing investigator sites across multiple CROs and sponsors. AI tracks essential documents, regulatory submissions, and enrollment metrics per site — giving your operations team a unified view instead of logging into 15 different sponsor portals.

Common Questions About AI Workflows for CROs

Does this integrate with our CTMS and eTMF systems?
We connect to Veeva Vault, Medidata Rave, Oracle Clinical, MasterControl, Montrium, and any system that outputs data. The AI sits on top of your existing stack — no rip-and-replace.
How does this handle ICH-GCP compliance requirements?
Every workflow is built with ICH-GCP controls — audit trails, role-based access, data integrity checks, and human-in-the-loop review for clinical decisions. AI processes and validates documentation. Your qualified personnel retain clinical oversight.
We manage 50+ concurrent studies across multiple sponsors. Can AI handle that complexity?
That’s where AI shines. The more sponsors, studies, and sites you manage, the higher the ROI. AI normalizes data from different sponsor CTMS platforms, different eTMF structures, different safety databases. Same output quality regardless of the sponsor’s technology stack.
What about 21 CFR Part 11 and Annex 11 requirements?
We design workflows with Part 11 and Annex 11 in mind — electronic signatures, audit trails, system access controls, and documented validation. Your quality team owns validation; we provide the technical framework that supports it.
What’s the ROI look like for an enterprise CRO?
Enterprise CROs managing 50+ studies typically see $1.5M–$3M in annual savings from reduced TMF remediation, faster regulatory submissions, and eliminated manual report compilation. The AI Roadmap identifies the exact number for your operation.
We have a large IT and quality team. Why not build this in-house?
Your IT team knows your systems. Your quality team knows GCP. We know AI workflow automation. Most enterprise AI projects fail because they’re treated as IT projects rather than operations projects. We bring the AI expertise; your team brings the clinical and regulatory domain knowledge.
How long until we see results?
First workflow live in 60 days. Most enterprise CROs start with TMF management or site monitoring reports because the volume is high and the payback is immediate.
How does this prepare us for sponsor audits and regulatory inspections?
AI maintains TMF completeness in real-time — every essential document tracked, every gap flagged the day it appears. When a sponsor audit or FDA inspection lands, your TMF is already inspection-ready. No 6-week remediation scramble.

Your Trial Portfolio Is Too Complex for Manual Documentation Workflows

Book a free 30-minute AI Assessment. We’ll map your highest-volume documentation workflows, identify where manual processes are costing you millions in overhead, and show you the 3 workflows with the highest ROI.

First workflow live in 60 days. Cancel the retainer with 30 days notice. No lock-in.